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Oxidants

Oxidants exhibit a wide array of tissue-damaging cytotoxic effects, reacting with and attacking a variety of biomolecules, including proteins, lipids, and DNA. Low concentrations of oxidants usually trigger apoptotic death, whereas higher concentrations induce necrosis with cellular energetic (ATP and NAD) serving as a switch between the two modes of cell death. At higher concentrations, oxidants damage DNA, triggering the activation of DNA repair systems including poly(ADP-ribose) polymerase (PARP). Oxidant-induced over activation of PARP consumes NAD⁺ and consequently ATP, culminating in cell dysfunction and necrosis.

Oxidants can also stimulate inflammatory gene expression and have a profound effect on protein function, via the oxidation or nitration of critical amino acid residues. Peroxynitrite can also trigger the activation of metalloproteinase's via post-translational nitrosation. Oxidants have no other apparent physiological function. The association of peroxynitrite and other damaging oxidants (including hydroxyl, nitroxyl anion, and hydrogen peroxide) with a variety of important clinical conditions has been well established. These conditions include acute conditions such as acute myocardial infarction and organ transplantation and chronic conditions associated with progressive tissue damage, such as age-related macular degeneration, arthritis, and diabetes mellitus.

Toxins

Toxins are substances created by plants and animals that are poisonous to humans. Most toxins that cause problems in humans are released by microorganisms such as bacteria and viruses.

Many natural health proponents believe that the body accumulates toxins which should be periodically flushed. While the body does naturally process and eliminate toxins, increased exposure to environmental toxins combined with drug use and unhealthy diets across much of the First World sometimes proves to be too much for the body to process, leading to health problems. By detoxifying the body, many people feel that they improve their health and state of mind, and are able to lead more balanced lives.

The body naturally processes toxins through the liver, kidneys, and lower intestines. These organs take in toxins and either convert them to a usable form or push them out of the body, so that they cannot damage other, more delicate organs. People who lead healthy, active lifestyles probably do not need to take extra steps to remove the toxins from their bodies. However, if you eat a high fat, high sugar diet, consume caffeine, alcohol, cigarettes, or drugs, are exposed to dangerous chemicals, or get limited exercise, you may want to consider removing the toxins from your body and making life changes to keep your body healthy.